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(A) Adherence to Tenofovir disoproxil fumarate can be determined from concentrations of TFV (in plasma, half-life ~15 h) and/or TFV-DP (in red blood cells, half-life ~17 days). TFV-DP is cleared more slowly, so the concentration is better correlated with the long-term average dosing rate. (B) Tenofovir conjugates used in this study.
