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Measurement of binding affinities between the three compounds (EP, PEP and MEP) and human ACE2 (left column) or SARS-CoV-2 RBD (right column) by surface plasmon resonance assay. Purified recombinant SARS-CoV-2 RBD or recombinant human ACE2 were covalently immobilized to the sensor chip via their amine groups, and EPs flowed by. Here EPs was diluted to different concentrations (from 12.5 to 100 μM) before being injected. Data are shown as different colored lines
