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. 2021 Feb 15;47(4):55. doi: 10.3892/ijmm.2021.4888

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Structure of TGF-βR1 and TGF-βR2. TGF-βR1 and TGF-βR2 contain multiple cysteines and a signal sequence in the extracellular region. In the intracellular region near the membrane, TGF-βR1 contains a region rich in glycine and serine that is associated with its autophosphorylation, and TGF-βR2 contains a region rich in serine and threonine that can phosphorylate TGF-βR1 during signal transduction, activating the TGF-βR1 kinase region. TGF-βR1/2, TGF-β receptor 1/2; Cys, cysteine; GS, glycine and serine domain; ST, serine and threonine domain.