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Structure and efficacy of TDF and TAF monotherapy in the HBV treatment. (a) TDF and TAF are the prodrugs of tenofovir. (b) Clinical efficacy of TDF and TDF in HBV-infected patients treated with either adefovir dipivoxil 10 mg or TDF 300 mg, TAF 25 mg. Efficacy data from phase 3 or 4 trials were summarized in Table 2.
