Table 3.
Central analgesic activity of DGALE using hot plate test in rats.
| Groups | Reaction time (sec.) |
%MPE | |||
|---|---|---|---|---|---|
| 0 min | 30 min | 60 min | 90 min | ||
| Control | 8.2 ± 0.90 | 7.7b ± 0.48 | 8.3b ± 1.10 | 8.8b ± 1.25 | 1.0b ± 1.41 |
| DGALE (100 mg/kg) | 7.0 ± 0.64 | 7.3b ± 1.03 | 7.6b ± 0.85 | 7.4b ± 0.82 | 0.8b ± 0.57 |
| DGALE (200 mg/kg) | 7.1 ± 0.52 | 7.0b ± 0.98 | 7.7b ± 0.79 | 7.8b ± 0.45 | 1.3b ± 0.22 |
| DGALE (300 mg/kg) | 7.0 ± 0.31 | 7.3b ± 1.29 | 8.0b ± 0.94 | 8.7b ± 0.62 | 3.1ab ± 0.82 |
| Acetyl salicylic acid (150 mg/kg) | 8.0 ± 1.48 | 10.8a ±2.29 | 12.2a ±1.72 | 13.3a ±1.00 | 10.1a ±1.00 |
Each value represents the mean of 5 rats ±S.D. Statistical analysis was performed using two-way ANOVA followed by Tukey-Kramer multiple comparisons test. (a vs positive control group at same time interval, b vs acetyl salicylic acid group at same time) at p ≤ 0.05.
MPE refers to the maximal possible effect.