Table 2.

Potential role of statins in COVID-19

Potential role of statins	Molecular mechanism of action	References
Preventing SARS-CoV-2 Entry	Modulation of CD-147 expression	[45]
Inhibiting SARS-CoV-2 Replication	Interaction viral main protease (Mpro)	[46]
Attenuating hyperinflammatory response and cytokine storms	Modulation of Toll-like receptor (TLR) and NOD-like receptor activities Reduction of IL-6 and IL-1β cytokines	[49] [50]
Modulating hypercoagulability	Decreased plasma levels of von Willebrand factor antigen (vWF:Ag) and plasma endothelin-1 concentrations	[53, 54]
Mitigating lung injury	Increased expression of ACE2*	[41, 42]

SARS-CoV-2 Severe Acute Respiratory Syndrome Coronavirus-2, COVID-19 Coronavirus disease-2019, ARDS Acute Respiratory Distress Syndrome, ACE2 angiotensin-converting enzyme 2, IL-6 Interleukin-6, IL-1β Interleukin-1β

*Still controversial