Table 2.
Summary of clinical studies on diastolic function in primary aldosteronism.
| Author & year | Assessment method | Study vs. control group | Diastolic function |
|---|---|---|---|
| Rossi et al. (1996) [12] | Ei/Ai, ACLVF | 34 PA vs. 34 EH | PA patients with significantly lower Ei/Ai & higher ACLVF |
| Rossi et al. (1997) [13] | Ei/Ai, ACLVF | 26 APA vs. 26 EH | APA patients with significantly lower Ei/Ai & higher ACLVF |
| Tanabi et al. (1997) [15] | E/A | 20 PA vs. 47 EH | No significant difference |
| Rossi et al. (2002) [16] | E/A, ACLVF | 17 PA vs. 10 EH | PA patients with significantly lower E/A & higher ACLVF |
| Catena et al. (2007) [62] | E/A, DT | 54 PA vs. 274 EH | PA patients with significantly lower E/A & higher DA |
| Tsioufis et al. (2008) [130] | E/A, DT, Em, Em/Am | 17 PA vs. 30 EH | E/A & DT no significant difference. PA patients with significant lower Em & Em/Am |
| Muiesan et al. (2008) [64] | E/A, DT | 125 PA vs. 125 EH (matched age/sex/BP) | No significant difference |
| Galetta et al. (2009) [78] | Em, Am, Em/Am | 23 PA vs. 24 EH | PA patients with significantly lower Em, higher Am, & lower Em/Am |
| Lin et al. (2011) [67] | Ei/Ai | 11 PA vs. 17 EH | No significant difference |
| Lin et al. (2012) [73] | Ei/Ai | 20 APA vs. 20 EH | No significant difference |
| Su et al. (2012) [80] | Tdec in cine MRI | 25 PA vs. 12 age-matched healthy subjects | PA patients with significantly shorter Tdec |
| Lee et al. (2013) [81] | DT, Ei/Ai | 62 PA vs. 17 EH | No significant difference |
| Hung et al. (2015) [84] | Em, E/Em | 27 APA vs. 27 EH | APA patients with significantly lower Em and higher E/Em |
| Cesari et al. (2016) [71] | Em, E/Em | 51 PA vs. 61 healthy subjects | PA patients with significantly lower Em and higher E/Em |
| Yang et al. (2017) [72] | Em, E/Em | 100 PA vs. 100 EH | PA patients with significantly lower Em and higher E/Em, but no difference in LVMI compared with EH |
| Chang et al. (2019) [93] | Em, E/Em | 105 APA vs. 105 EH matched age, sex, BMI, SBP, DBP, duration of hypertension & number of anti-hypertension drugs | APA patients with significantly lower Em and higher E/Em independently of hemodynamic effects |
Ei/Ai E wave and A wave flow velocity integral ratio, E/A E wave and A wave flow velocity ratio, ACLVF atrial contribution to left ventricular filling, DT E wave deceleration time, Em peak early diastolic velocity of mitral annulus, Am peak atrial systolic velocity of mitral annulus, BP blood pressure, APA aldosterone-producing adenomas, Tdec time for deceleration of LV volume-time curve, BMI body mass index.