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. 2020 Nov 26;35(2):176–186. doi: 10.1007/s12149-020-01550-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Lesion-to-liver uptake ratio versus the noise in the liver (standard deviation) for two malignant lesions of clinical PET/CT studies. Each small circle or cross indicates iteration/subset pairs used for the reconstruction of PET images. The target PET images were reconstructed using 2 iterations and 21 subsets (2i, 21s). The selected iteration/subset pairs for implementation of the MR-NLM filter includes 2i:24s, 2i:28s, 3i:14s, 3i:12s, 3i:21s, 4i:12s, 4i:8s, 5i:8s, 5i:7s, 5i:6s, 6i:7s, and 7i:6s. These pairs are enclosed in the blue and red circles