Skip to main content
. 2021 Feb;124:105096. doi: 10.1016/j.psyneuen.2020.105096

Fig. 4.

Fig. 4

Functional connectivity of corticolimbic regions with the default mode, salience and executive control networks. (Left part of the figure) Green-purple colour heatmap of the correlation coefficient values (Spearman’s rank-order correlation test) between the 10 preselected ROIs and the main large-scale resting state brain networks (DMN, SN, ECN) per treatment group (SCC, SCP, PO) and subject. A mean value has been calculated from the resulting correlation coefficients per ROI and treatment group, and subsequently these mean values have been compared at treatment group-level after applying Fisher z-transformation (blue-red colourmap, significance threshold p < 0.05) (lower right part of the figure). As expected, based on prior knowledge, ROIs (belonging to the corticolimbic system of the brain) show higher functional connectivity to SN, and less to DMN (with the prominent exception of PCC) and ECN. Most ROIs are evenly or stronger connected with the three brain networks in the glucocorticoid treatment mode lacking the ultradian pulses (SCC) compared to the one comprising the approximation of the normal ultradian rhythm (SCP), with the exception of the PCC whose connectivity with DMN is stronger in SCP compared to SCC. Similarly, most ROIs are evenly or stronger connected with the three brain networks in the oral glucocorticoid treatment (PO) compared to the one comprising the approximation of the normal ultradian rhythm (SCP), with the exceptions of the functional connectivities of PCC with DMN, vACC with SN, and ROFC and RAI with ECN, which are is stronger in SCP compared to PO. DMN: default mode network, ECN: executive control network, PCC: posterior cingulate, RAI: right anterior insula, RAmy: right amygdala, RCau: right caudate, RHipp: right hippocampus, RNA: right nucleus accumbens, ROFC: right orbitofrontal cortex, ROIs: regions of interest, RPut: right putamen, sACC: middle part of the anterior cingulate, SN: salience network, vACC: ventral part of the anterior cingulate PO: oral treatment group, SCC: subcutaneous-continuous treatment group, SCP: subcutaneous-pulsatile treatment group. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)