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. 2021 Feb 19;12(2):200. doi: 10.1038/s41419-021-03488-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Upregulation of TGFβ downstream target genes related to TME reprogramming in EGFP or TGFβ1 activated liver tumors. Student t test was applied for statistical analysis. b, c Upregulation of TGFβ downstream target genes related to TME in EGFP or TGFβ1 activated b HCC3-4 cell lines and c HCC4-4 cell lines. Student t test was applied for statistical analysis. d Quantitative RT-PCR results showing downregulation of Pmepa1 in TGFβ1 activated HCC3-4 and HCC4-4 cell lines after siPmepa1 transfection (N = 6 replicates in each group). Student t test was applied for statistical analysis. e, f Representative images and quantification of cell healing assay at 0-hour (0 h) and after 48 hours (48 h) treatment following TGFβ1 overexpression as well as scrambled siRNA (siSC) or siPmepa1 transfection. Student t-test was applied for statistical analysis. P-values were as shown. Experiments were conducted three times. g, h Representative images and quantification of transwell assay 48 h after treatment following TGFβ1 overexpression as well as scrambled siRNA (siSC) or siPmepa1 transfection. Student t-test was applied for statistical analysis. P-values were as shown. Experiments were conducted three times.