Table 3.
Increased prevalence of malignancy in NELL1-associated MN, compared to PLA2R-associated MN, THSD7A-associated MN, and membranous nephropathy due to unknown antigens. The types and frequencies of tumors seen in patients with malignancy-associated membranous nephropathy are shown.
| Type of neoplasm | PLA2R positive (n=35 of 829) | THSD7A positive (n=4 of 37) | NELL1 positive (n=30 of 91) | Unknown antigen (n=42 of 421) |
|---|---|---|---|---|
| Prostate adenocarcinoma | 10 | 3 | 6 | 10 |
| Breast carcinoma | 12 | 1 | 5 | 8 |
| Gastric carcinoma | 0 | 0 | 1 | 2 |
| Soft tissue tumor | 0 | 0 | 1 | 0 |
| Glioma | 0 | 0 | 1 | 0 |
| Colon adenocarcinoma | 1 | 0 | 1 | 6 |
| Lung carcinoma | 1 | 0 | 3 | 4 |
| Bladder carcinoma | 5 | 0 | 2 | 0 |
| Renal cell carcinoma | 2 | 1 | 3 | 5 |
| Pancreatic carcinoma | 0 | 0 | 0 | 1 |
| Hepatocellular carcinoma | 0 | 0 | 0 | 1 |
| Thyroid carcinoma | 0 | 0 | 1 | 2 |
| Ovarian carcinoma | 0 | 0 | 1 | 0 |
| Uterine carcinoma | 0 | 0 | 0 | 1 |
| Cervical carcinoma | 1 | 0 | 1 | 0 |
| Testicular carcinoma | 1 | 0 | 0 | 0 |
| Skin (melanoma, BCC, SCC) | 2 | 0 | 4 | 1 |
| Squamous cell carcinoma (head/neck) | 0 | 1 | 1 | 2 |
| Laryngeal carcinoma | 0 | 0 | 0 | 1 |
| Nasopharyngeal carcinoma | 0 | 0 | 1 | 0 |
| Thymoma | 0 | 0 | 1 | 0 |
| Lymphoma | 0 | 0 | 1 | 1 |
| Total | 35 | 6* | 34** | 45*** |
*
While 4 patients in the THSD7A positive cohort had a history of malignancy, the number of tumors is >4 due to two patients with two primary tumors.
**
While 30 patients in the NELL1 positive cohort had a history of malignancy, the number of tumors is >30 due to four patients with two primary tumors.
***
42 patients with MN of unknown type had a history of malignancy, and the number of tumors is >42 due to three patients with two primary tumors.