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. 2021 Jan 19;108(2):309–323. doi: 10.1016/j.ajhg.2021.01.002

Figure 4.

Figure 4

Immunofluorescence staining of CFAP47 in the spermatozoa from a male control individual and men harboring hemizygous CFAP47 variants

Sperm cells were stained with anti-CFAP47 (red) and anti-α-tubulin (green) antibodies. DNA was counterstained with DAPI (4′,6-diamidino-2-phenylindole) as a marker of the cell nucleus. CFAP47 staining is concentrated at the base of sperm flagella from the control individual, but the signal was almost absent in the sperm flagella from men harboring hemizygous CFAP47 variants. Scale bars: 5 μm.