Table 3.

Incidence of most frequent adverse events.

Adverse event	Number of patients (%)
Musculoskeletal and connective tissue disorders	53 (38.1)
Asthenia	48 (34.5)
Injection site reactions	30 (21.6)
Nausea	18 (12.9)
Decreased appetite	18 (12.9)
Diarrhea	15 (10.8)
Headache	13 (9.4)
Dyspnea	13 (9.4)
Peripheral neuropathy	11 (7.9)
Palmar-plantar erythrodysesthesia syndrome	11 (7.9)
Vomiting	10 (7.2)
Abdominal pain—upper	8 (5.8)
Neutropenia	7 (5.0)
Constipation	7 (5.0)
Rash	7 (5.0)
Hot flush	7 (5.0)