Table 2.

Correlation between metabolite levels and Griffiths-III or WPPSI-III test scores.

		Griffiths-III test			WPPSI-III test
		A AE	B AE	IQ	Total AE	Verbal AE	Non-verbal AE	IQ
Hcy n = 28 (G) n = 49 (W)	r	0.092	0.257	0.174	− 0.346	− 0.329	− 0.204	− 0.376
	p-value	0.660	0.216	0.375	0.016*	0.022*	0.164	0.008*
Folate n = 26 (G) n = 49 (W)	r	0.347	0.099	0.370	0.104	0.158	− 0.049	0.112
	p-value	0.089	0.638	0.063	0.482	0.285	0.741	0.442
Uric acid n = 12 (G) n = 27 (W)	r	0.410*	0.575*	0.363	− 0.023	− 0.161	0.267	− 0.189
	p-value	0.239	0.082	0.247	0.912	0.433	0.187	0.346
Creatinine n = 28 (G) n = 49 (W)	r	0.023	0.194	0.028	0.061	0.007	0.132	− 0.135
	p-value	0.913	0.353	0.888	0.679	0.963	0.369	0.355
Vit. B12 n = 11 (G) n = 27 (W)	r	0.054	0.313	0.117	0.282	0.276	0.169	0.386
	p-value	0.881	0.349	0.733	0.163	0.172	0.409	0.046*

Partial correlations (r) correct by age was done between Griffiths-III or WPPSI-III subtest scores and metabolite levels; bivariate correlations (r) were done between IQ scores and metabolite levels. Correlation between vitamin B12 (Vit. B12)/UA levels and Griffiths-III or WPPSI-III test scores was analyzed only in fasting subjects. The analysis includes outliers. Further analysis after outlier exclusion is described in the text.

AE age equivalent, A evaluation of “foundations of learning”, B evaluation of “language and communication”, IQ intelligence quotient, (G) number of subjects with Griffiths-III test scores, (W) number of subjects with WPPSI-III test scores.

*p-value ≤ 0.05 or moderate correlation 0.4 < r < 0.7.