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. 2021 Feb 19;12:1146. doi: 10.1038/s41467-021-21280-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a SNP-based heritability of the five digestion phenotypes both on the observed and liability scales. The transformation to the liability scale uses the UKB sample risk, i.e., the proportion cases in the UKB cohort, as the population lifetime risk; the sample risk percentage of whole UKB European ancestry is shown below the x-axis in parentheses. The error bars represent 95% confidence interval for the estimated SNP-based heritability. “*” represents that the SNP-based heritability P value remain significant after Bonferroni correction (P < 0.05/10). b, c Results for genetic correlation within-digestion phenotypes and between digestion phenotypes and the nine psychiatric and neurological disorder traits are in b, while genetic correlation results between digestion phenotypes and traits from LD Hub that had a significant correlation with at least one of the digestion phenotypes are provided in b, c. “*” represent that genetic correlation estimates are still significant after Bonferroni correction (P < 0.05/((5 + 9 + 258) * 5)).