Table 1.
Full-sibling relative risk and heritability estimation for PUD, GORD, IBS, and IBD.
| Digestion phenotypes | ||||
|---|---|---|---|---|
| PUD | GORD | IBS | IBD | |
| N case:N control* | 16666:439661 | 54854:401473 | 29524:426803 | 7045:449282 |
| N case/(N case + N control) | 0.037 | 0.120 | 0.065 | 0.015 |
| No. of male case:No. of female case | 9641:702s5 | 24841:30013 | 7981:21543 | 3432:3613 |
| No. of male control:No. of female control | 199156:240505 | 183956:217517 | 200816:225987 | 205365:243917 |
| Odds of being male case/Odds of being female case | 0.048/0.029 | 0.135/0.138 | 0.040/0.095 | 0.017/0.015 |
| Male:female odds ratio for being case | 1.66 | 0.98 | 0.42 | 1.13 |
| No. of full-sibling pairs where both proband and full-sibling are cases | 104 | 940 | 236 | 38 |
| No. of full-sibling pairs where only the proband is a case | 1460 | 4530 | 2682 | 630 |
| Full-sibling relative risk (95% confidence interval) | 1.82 (1.51–2.19) | 1.43 (1.35–1.52) | 1.25 (1.11–1.41) | 3.68 (2.70–5.02) |
| Heritability (95% confidence interval)† | 0.28 (0.18–0.37) | 0.28 (0.23–0.33) | 0.12 (0.05–0.19) | 0.49 (0.36–0.64) |
*The number for the cases and controls of each digestion phenotypes are from the whole UK Biobank individuals with European ancestry, i.e., related individuals are included.
†The corresponding lower and upper values of 95% confidence interval (CI) for risk in full-sibling were used to calculate the 95% CI for heritability estimation.