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. 2021 Feb 19;12(2):197. doi: 10.1038/s41419-021-03480-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A UCSC genome browser tracks showing representative replicate ATAC-seq and CUT&Tag at the Klf4 locus. BMP2-dependent NFRs at Klf4 locus were named as K1 to K6. K2 and K6 are shaded in green. B Dual luciferase assay showing the relative enhancer activity of K2 and K6 in MC3T3-E1. n = 3, ***P < 0.001, ****P < 0.0001. C Double immunofluorescence staining of KLF4 and SP7 in 4-week-old Bmp2^fx/fx (BMP2-WT) and Sp7-Cre; Bmp2^fx/fx (BMP2-cKO) femurs. The image part was shown in the sketch on the left. n = 3.