Figure 2.
G-CSF reduces cue-primed but not cocaine-primed drug seeking when administered during abstinence. A, Schematic for experiment 2. B, Rats later assigned to PBS or G-CSF groups did not differ in their active or (C) inactive pressing during acquisition of cocaine self-administration (0.8 mg/kg/infusion, FR1), but there was a main effect of session on active lever pressing (F(3.84,52.86) = 8.77, p < 0.0001). Additionally, pretreatment groups did not differ in active (D) lever pressing or (E) inactive lever presses during extinction, but there was a main effect of session on previously active lever pressing (F(1.13,13.53) = 15.77, p < 0.01). F, G-CSF treatment during abstinence reduced responding for cue-induced drug seeking (t(15) = 2.45, p < 0.05). However, there was no effect during cocaine-primed seeking (G, t(15) = 0.08, p > 0.05). All data presented as means ± SEM; *p < 0.05, main treatment effect.