G-CSF treatment leads to updated response output over the course of cue-induced seeking session. A, G-CSF-treated and PBS-treated rats did not differ in lever pressing within the first 10% of the cue-induced reinstatement session (t(15) = 1.79, p > 0.05), but significantly differed during the final 10% of the session (t(15) = 16.25, p < 0.0001). B, G-CSF-treated and PBS-treated rats did not differ in the first 10% of their cocaine-primed reinstatement session nor the final 10% (first 10%: t(15) = 0.01, p > 0.05; final 10%: t(15) = 0.92, p > 0.05). Black lines = PBS, green lines = G-CSF, black and green shading colors above and below indicate SEM.