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Angiotensin-II excites neurons in the MnPO/OVLT, and this response is attenuated by antagonism of AT1aR. A, AAV delivery of Cre-dependent GCaMP6f into the MnPO/OVLT of Agtr1a-Cre mice mouse selectively transforms AT1aR neurons. B, Exposure to Ang-II (1 μm, 3 min) increases fluorescence in GGaMP6f-expressing neurons. C, The excitatory action of Ang-II (n = 6, blue trace) is attenuated by pretreatment with Losartan (10 μm, n = 4, red trace). aca, anterior commissure. Scale bars, 250 µm.
