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. 2021 Feb 19;11:4252. doi: 10.1038/s41598-021-83215-y

Figure 5.

Figure 5

Pre-treating PC3 cells with PLK1 and CDK inhibitors for 24 h prior to radiation, enhances in cell death. (a) Cell counts of PC3 primed to radiation (Xrad) with the PLK1 inhibitor BI2536 (100 nM) for 24 h. Counts were taken at 72 h from the radiation (2, 4 and 8 Gy). Radiation Enhancement Ratio (RER) is shown for BI2536 (100 nM) and Radiation (2, 4 and 8 Gy) and calculated out of 3 independent experiments. (b) Cell counts of PC3 primed to radiation (Xrad) with a sub-toxic concentration of the CDKs inhibitor Dinaciclib for 24 h (0.1 nM). Radiation Enhancement Ratio (RER) is shown for Dinaciclib (0.1 nM) and Radiation (2, 4 and 8 Gy) and calculated out of 3 independent experiments. One-way ANOVA test has been run comparing treated vs Vehicle and mock radiated on n = 3 experiments, *p ≤ 0.05; **p < 0.01; ***p < 0.001 (± SD).