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. 2021 Feb 19;12:1164. doi: 10.1038/s41467-021-21446-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Fold enrichment of per-SNP heritability against that of polygenicity. b Fold enrichment of per-NZE (per-nonzero effect) heritability against that of polygenicity. Colours indicate different annotation categories. c Estimated S (green) across annotation categories ranked by per-SNP heritability enrichment (red). Each dot or histogram is the median across 35 UKB traits (including diseases). Each bar indicates the standard error of the mean.