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. 2021 Feb 19;12:1160. doi: 10.1038/s41467-021-21429-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Whole brains (5 DPE) labeled with anti-PDF in transgenic glial driver control (repo-Gal4/+, top) and expressing dfmr1-RNAi targeted to glia (repo-Gal4 > dfmr1-RNAi³⁵²⁰⁰, bottom). Both genotypes exhibit a lack of PDF-Tri neurons in the central brain. Right: Graphs showing central PDF-Tri area (left) and PDF+ puncta (right) in the two genotypes. Area: two-sided Mann–Whitney, p = 0.5700, 98.62 ± 32.84 n = 15 control, 38.84 ± 16.17 n = 12 dfmr1-RNAi; puncta: two-sided t test, p = 0.2650, 14.79 ± 4.432 n = 14 control, 9.063 ± 2.676 n = 16 dfmr1-RNAi. b Brains (5 DPE) labeled with anti-PDF in the transgenic neuron driver control (elav-Gal4/+, top) and expressing dfmr1-RNAi targeted to neurons (elav-Gal4 > dfmr1-RNAi³⁵²⁰⁰, bottom). The PDF-Tri neurons are absent in controls, but persist when FMRP function is removed in neurons (arrows). Right: Graphs showing anti-PDF area (left) and PDF+ puncta (right) in the two genotypes. Area: two-sided t test, p = 0.0105, 108.1 ± 40.93 n = 11 control, 303.7 ± 51.3 n = 16 dfmr1-RNAi; puncta: two-sided t test, p = 0.0018, 11.91 ± 3.706 n = 11 control, 36.38 ± 5.169 n = 16 dfmr1-RNAi. Scatter plot graphs show mean ± SEM. Sample size is n = number of animals. Significance shown for p > 0.05 (not significant, N.S.), p < 0.05 (*), and p < 0.01 (**). Scale bar: 50 μm. Source data for this figure are provided in Source Data file.