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. 2020 Mar 2;41(11):1553–1564. doi: 10.1093/carcin/bgaa019

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Figure 6. — DeconstructSigs trinucleotide signatures in the pre-neoplastic and tumor LSCCs. The mutational signatures in the pre-neoplastic and tumor LSCCs. As explained in detail in Supplementary Methods, available at Carcinogenesis Online, this analysis infers the composition of 30 canonical COSMIC signatures based on the 96-substitution combination, indicated on the x-axis, whereas on the y-axis, we indicated the fraction of each substitution combination. Next to each signature, the pie diagram shows the frequency of each represented mutational signature, color-coded. The color-coded legend describes the number and name of each mutational signature according to the 30 canonical COSMIC signatures.