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. 2020 Jun 30;41(11):1529–1542. doi: 10.1093/carcin/bgaa064

Figure 2.

Figure 2.

Oophorectomy in LR/Stat3Δ/Δ female mice reprogrammed lung tumor microenvironment to a pro-tumor phenotype, and estrogen replacement reversed these changes. (a) Total inflammatory cell and lineage-specific leukocyte numbers from BALF (n = 5–9). (b) Relative mRNA expression of Retnla1, Arg1, Mrc1 and Ido1 mRNA in BALF inflammatory cells, normalized by Cd45 expression (n = 4). (c) Relative mRNA expression of Ccl2, Cxcl1, Il6, Il17a, Tgfb1, Tbx21, Gzmb, Foxp3, Ifng, Il10, Arg1, Ido1 and Nos2 in the whole lung, normalized by Cd45 expression. (d) Relative mRNA expression of IκBα in the whole lung normalized to β-actin. (e) Fold change of p65 binding activity represented by fold change of OD value. Data represent mean ± SEM; ****P < 0.0001, ***P < 0.001, **P < 0.01, *P < 0.05, experimental replicate #3.