Table 1.
Comparison of different characteristics in high- vs low-risk pregnancies complicated by severe acute respiratory syndrome coronavirus 2 infection
| Characteristic | High-risk pregnancies(n=208) | No high-risk pregnancies(n=679) | P value |
|---|---|---|---|
| Maternal and pregnancy characteristics | |||
| Maternal age | 34.16±6.80 | 31.39±5.50 | <.001a |
| Gestational age at diagnosis of infection (wk) | 30.26±9.80 | 29.65±9.60 | .425 |
| Nulliparity | 75 (36.1) | 219 (32.3) | .313 |
| Smoking before or during pregnancy | 11 (5.3) | 21 (3.1) | .140 |
| Preterm birth at <37 wk of gestation | 33 (15.9) | 61 (9.0) | .007a |
| Preterm birth at <34 wk of gestation | 14 (6.7) | 27 (4.0) | .129 |
| Vaginal delivery | 145 (69.7) | 527 (77.6) | .026a |
| Cesarean delivery | 63 (30.3) | 152 (22.4) | .026a |
| Clinical, radiological and laboratory findings | |||
| Symptomatic infection | 106 (51.0) | 411 (60.5) | .016a |
| Asymptomatic infection | 102 (49.0) | 268 (39.5) | .016a |
| Fever | 50 (24.0) | 206 (30.3) | .081 |
| High-grade fever | 20 (9.6) | 14 (2.1) | <.001a |
| Cough | 52 (25.0) | 185 (27.2) | .591 |
| Myalgia | 28 (13.5) | 129 (19.0) | .078 |
| Anosmia | 11 (5.3) | 47 (6.9) | .521 |
| GI symptoms | 4 (1.9) | 23 (3.9) | .360 |
| Positive chest CT scan | 34 (16.3) | 20 (2.9) | <.001a |
| Lymphopenia | 109 (52.4) | 311 (45.8) | .096 |
| Thrombocytopenia | 27 (13.0) | 31 (4.6) | <.001a |
| Increased LDH levels | 29 (13.9) | 24 (3.5) | <.001a |
| Pharmacologic treatments | |||
| LMWH | 58 (27.9) | 125 (18.4) | .139 |
| Antibiotics | 61 (29.3) | 209 (30.8) | .731 |
| Any antiviral drug | 67 (32.2) | 142 (20.9) | <.001a |
| Hydroxychloroquine | 46 (22.1) | 122 (18.0) | .189 |
Data are presented as number (percentage) or mean±standard deviation.
CT, computerized tomography; LDH, lactate dehydrogenase; LMWH, low-molecular-weight heparin.
D'Antonio. Outcome of severe acute respiratory syndrome coronavirus 2 in high- vs low-risk pregnancies. Am J Obstet Gynecol MFM 2021.
a
Values are statistically significant.