Figure 2.

Gene-expression regulation by 1B3 in individual cell lines

(A) Numbers of differentially expressed (DE) genes that are downregulated (estimated expression 1B3/estimated expression mock < 1) and upregulated (estimated expression 1B3/estimated expression mock > 1) 24 h and 72 h after transfection with 10 nM 1B3 in each cell line are shown as compared to mock-transfection conditions. The number of downregulated genes that are predicted miR-193a-3p targets is also indicated. (B) Heatmaps showing differential gene expression induced by 1B3 per cell line at 24 h and 72 h post-transfection. All DE genes are on the y axis and on the same row across all cell lines and both time points (due to the long list, gene names are not shown). Green means downregulated, and red means upregulated genes. Gray means no observed change in gene expression.