Table 2.

Three-dimensional structures of disaccharide phosphorylases.

Family	Fold	Clan	EC No.	Enzyme	Organism	PDB code	Ligand	Ref.
GT4	GT-B		2.4.1.231	α,α-Trehalose phosphorylase
GH13	(β/α)8	GH-H	2.4.1.7	Sucrose phosphorylase	Bifidobacterium adolescentis	5M9X, 5MAN, 2GDV	Glycosylated resveratrol, sucrose, nigerose	[36]
			2.4.1.352	Glucosylglycerate phosphorylase
			2.4.1.359	1,2-α-glucosylglycerol phosphorylase
GH65	(α/α)6	GH-L	2.4.1.64	α,α-trehalose phosphorylase
			2.4.1.216	Trehalose 6-phosphate phosphorylase
			2.4.1.230	Kojibiose phosphorylase	Caldicellulosiruptor saccharolyticus	3WIQ, 3WIR	Kojibiose, Glc	[37]
			2.4.1.279	Nigerose phosphorylase
			2.4.1.8	Maltose phosphorylase	Lactobacillus brevis	1H54		[38]
			2.4.1.332	Glucosylglycerol phosphorylase	Bacillus selenitireducens	4KTP, 4KTR	Glc, isofagomine and glycerol	[39]
			2.4.1.282	3-O-α-d-glucosyl-l-rhamnose phosphorylase
GH94	(α/α)6	GH-L	2.4.1.31	Laminaribiose phosphorylase	Paenibacillus sp.	6GH2, 6GH3,6GGY	G1P, Man1P, sulfate	[40]
			2.4.1.20	Cellobiose phosphorylase	Cellulomonas uda	3S4A, 3S4B, 3RSY	Cellobiose, Glc, sulfate and glycerol	[35,41,42]
					Clostridium thermocellum	3QDE	Phosphate
					Cellvibrio gilvus	3QFY, 2CQS, 3QFZ, 2CQT, 3QG0	Sulfate, phosphate, isofagomine, 1-deoxynojirimycin
			2.4.1.280	N,N′-diacetylchitobiose phosphorylase	Vibrio proteolyticus	1V7W	GlcNAc	[43]
			2.4.1.321	Cellobionic acid phosphorylase	Saccharophagus degradans	4ZLF	Cellobionic acid	[44]
GH112	(β/α)8	GH-A	2.4.1.211	1,3-β-Galactosyl-N-acetylhexosamine phosphorylase	Bifidobacterium longum	2ZUT	GalNAc	[45,46]
			2.4.1.247	β-d-galactosyl-(1 → 4)-l-rhamnose phosphorylase
GH130	5-Blade β-propeller		2.4.1.281	4-O-β-d-mannosyl-d-glucose phosphorylase	Bacteroides fragilis	3WAS	Man-Glc + PO4	[47,48]
					Ruminococcus albus	5AYC	Man-Glc + SO4
			2.4.1.320	1,4-β-Mannosyl-N-acetylglucosamine phosphorylase
			2.4.1.339	β-1,2-Mannobiose phosphorylase