Skip to main content
. Author manuscript; available in PMC: 2021 Feb 20.
Published in final edited form as: Nat Neurosci. 2020 Aug 10;23(9):1079–1089. doi: 10.1038/s41593-020-0686-7

Extended Data Fig. 8. Aquaporin-4 immunoreactivity and astrogliosis are unaffected by suppressing tau production with doxycycline in 7-8-month-old rTg4510 mice.

Extended Data Fig. 8

A. AQP-4 immunoreactivity, which labels astrocytic end-feet, was not disrupted in rTg4510 mice with or without doxycycline. N=5/group; two-way ANOVA with Tukey’s test; p=0.2420 between WT con & WT doxy, p=0.9985 between WT con & rTg4510 tau on, p=0.8585 between WT con & rTg4510 tau off, p=0.1881 between WT doxy & rTg4510 tau on, p=0.6502 between WT doxy & rTg4510 tau off, and p=0.7804 between rTg4510 tau on & off. Data are presented as mean±SEM. B. The astrogliosis (GFAP+ cells) observed in rTg4510 mice was not reduced with tau suppression. Data are presented as mean±SEM. N=5/group; two-way ANOVA with Tukey’s test. See Source Data 10 for statistical parameters.