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. Author manuscript; available in PMC: 2021 Feb 20.
Published in final edited form as: Nat Neurosci. 2020 Aug 10;23(9):1079–1089. doi: 10.1038/s41593-020-0686-7

Extended Data Fig. 9. MK-801 and TTX effect on CBF, L-NNA effect on NMDA-induced NO production and expression of NMDA receptor subunits in 2-3-month-old rTg4510 mice.

Extended Data Fig. 9

A. MK-801 and/or TTX have no effect on resting CBF or CBF response produced by neocortical superfusion of acetylcholine or adenosine. N=5/group. Data are presented as mean±SEM. B. NMDAR subunits mRNA levels are comparable in WT and rTg4510 mice. N=5/group. Data are presented as mean±SEM. C. Treatment with the NOS inhibitor L-NNA prevents NMDA-induced NO production in isolated cortical neurons from WT mice. Data are presented as mean±SEM. N=6/group; one-way ANOVA with Tukey’s test. See Source Data 11 for statistical parameters.