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. 2021 Feb 20;16:150. doi: 10.1186/s13018-021-02284-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Moringa oleifera attenuates H₂O₂-induced dysregulation of cell viability and cell cycle progression in BMSCs during osteogenic differentiation. a The effects of H₂O₂ at indicated concentrations and treatment times on cell viability in P3 cells. H₂O₂50, cells treated with 50 μmol/L H₂O₂; H₂O₂100, cells treated with 100 μmol/L H₂O₂; H₂O₂200, cells treated with 200 μmol/L H₂O₂. *P < 0.05 compared with the control group; ^#P < 0.05 compared with the H₂O₂50 group; ^@P < 0.05 compared with the H₂O₂100 group. b, c The effects of H₂O₂ and Moringa oleifera on cell viability and cell cycle progression of BMSCs during osteogenic differentiation. Cell viability (b) and cell cycle progression (c) of the indicated groups were measured at 48 h after initiation of osteogenic differentiation. Representative flow profile of cell cycle progression and percentage of cells in the G2 + S phases are shown. N = 3 for each group; *P < 0.05 compared with the control group; ^#P < 0.05 compared with the MO group; ^@P < 0.05 compared with the OS + H₂O₂ group