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. 2021 Feb 19;19:54. doi: 10.1186/s12957-021-02166-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — miR-378a-5p is underexpressed in CRC and inhibits colorectal cancer (CRC) tumorigenesis in vivo. a Heat map of differentially expressed microRNAs in CRC after statistical analysis of data downloaded from TCGA database. b miR-378a-5p levels in CRC tissue samples detected based on TCGA database. c miR-378a-5p levels in 22 CRC tissue samples and in matched adjacent noncarcinoma tissue samples assessed by qPCR. d miR-378a-5p expression in NCM460, SW620, HCT116, HT-29, and SW480 cells assessed by qPCR. qRT-PCR, real-time quantitative polymerase chain reaction. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001