Table 3.

Clinical Status Based on Seven-Point Ordinal Scale

Clinical Status	Progesterone Group (n = 18) [No. (%)]	Control Group (n = 22) [No. (%)]	P Valuea
Status at baseline, No. (%)
3: Hospitalized; on high-flow nasal cannula	3 (16.7)	0 (0.0)
4: Hospitalized; requiring supplemental oxygen (not HFNC)	11 (61.1)	20 (90.9)
5: Hospitalized; not requiring supplemental oxygen	4 (22.2)	2 (9.1)
Status on day 7, No. (%)
1: Death	1 (5.6)	0 (0.0)
2: Hospitalized; on invasive mechanical ventilation or ECMO	0 (0.0)	3 (13.6)
3: Hospitalized; on high-flow nasal cannula	2 (11.1)	3 (13.6)
4: Hospitalized; requiring supplemental oxygen (not HFNC)	2 (11.1)	8 (36.4)
5: Hospitalized; not requiring supplemental oxygen	4 (22.2)	4 (18.2)
6: Not hospitalized; limitations on activities	7 (38.9)	4 (18.2)
7: Not hospitalized; no limitations on activities	2 (11.1)	0 (0.0)
Change in status on day 7, No. (%)
+3	2 (11.1)	0 (0.0)
+2	7 (38.9)	3 (13.6)
+1	3 (16.7)	4 (18.2)
0	3 (16.7)	9 (40.9)
–1	2 (11.1)	3 (13.6)
–2	0 (0.0)	3 (13.6)
–3	1 (5.6)	0 (0.0)
Change in status on day 7, median (IQR)	1.5 (0.0 to 2.0)	0.0 (–1.0 to 1.0)	.024
Status on day 15, No. (%)
1: Death	1 (5.6)	1 (4.5)
2: Hospitalized; on invasive mechanical ventilation or ECMO	0 (0.0)	2 (9.1)
3: Hospitalized; on high-flow nasal cannula	0 (0.0)	2 (9.1)
4: Hospitalized; requiring supplemental oxygen (not HFNC)	1 (5.6)	0 (0.0)
5: Hospitalized; not requiring supplemental oxygen	1 (5.6)	1 (4.5)
6: Not hospitalized; limitations on activities	8 (44.4)	12 (54.5)
7: Not hospitalized; no limitations on activities	7 (38.9)	4 (18.2)
Change in status on day 15, No. (%)
+4	1 (5.6)	0 (0.0)
+3	7 (38.9)	2 (9.1)
+2	4 (22.2)	14 (63.6)
+1	4 (22.2)	1 (4.5)
0	1 (5.6)	0 (0.0)
–1	0 (0.0)	2 (9.1)
–2	0 (0.0)	2 (9.1)
–3	1 (5.6)	1 (4.5)
Change in status on day 15, median (IQR)	2.0 (1.0 to 3.0)	2.0 (1.0 to 2.0)	.150

ECMO = extracorporeal membrane oxygenation; HFNC = high-flow nasal cannula; IQR = interquartile range.

^aExact Wilcoxon rank-sum test.