FIGURE 2.

Comparison between NfL concentrations with the RS and alternative sample handling. Comparison of NfL concentrations using the RS versus (A) Noviplex DPS cards, (B) DBS cards, and (C) plasma stored at RT for 48 hours before analysis in the discovery cohort, as well as with (D) Noviplex DPS cards, (E) rocking for 3 hours at RT and then RT for 45 hours, and (F) 37°C incubation for 48 hours in the confirmatory cohort. Abbreviations: DBS, dried blood spots; DPS, dried plasma spots; NfL, neurofilament light; RS, reference standard; RT, room temperature. * = P < 0.05, ** = P < 0.01, *** = P < 0.001