Table 2.

Risk Factors for Lateral LNM in Children and Adolescent Patients with PTC

		Lateral LNM		p	B	OR	95% C.I.		P
		No	Yes				Lower Limit	Upper Limit
Age	≤15	8	23	0.001	0.770	2.16	0.677	6.897	0.193
	16–21	43	28		0	1
Sex	Female	41	35	0.173
	Male	10	16
Multifocality	Yes	5	26	<0.001	1.799	6.043	1.653	22.092	0.007
	No	46	25		0	1
DSV-PTC	Yes	1	7	0.027	0.414	1.513	0.122	18.714	0.747
	No	50	44		0	1
ETE	Minimal ETE	20	26	0.029	0.239	1.270	0.431	3.745	0.665
	Massive ETE	3	9		0.403	1.496	0.183	12.227	0.707
	No	28	16		0	1
LV invasion	Yes	3	5	0.461
	No	48	46
HT	Yes	9	13	0.336
	No	42	38
Intrathyroidal spreading	Yes	7	13	0.135
	No	44	38
Tumor Size		1.5 (1–2.5)	3 (2–4)	<0.001	0.561	1.752	1.043	2.945	0.034
The number of CLNM		3 (1–4)	5 (3–7))	<0.001	0.207	1.230	1.028	1.472	0.023

Notes: Variables in bold show statistical significance. Based on the regression coefficient from above logistic regression analysis, the formula for calculating prediction model of lateral LNM in children and adolescent patients with PTC can be obtained as follows: Combined predictor=Multifocality+(0.561/1.799) × Tumor size +(0.207/1.799) × The number of central LNM= Multifocality+ 0.31×Tumor size +0.115 × The number of central LNM.

Abbreviations: ETE, extrathyroidal extension; LV invasion, lymphatic vascular invasion; CLNM, central lymph nodes metastasis; DSV-PTC, diffuse sclerosing variant-papillary thyroid cancer; HT, Hashimoto’s thyroiditis.