Table 2.

Antidiarrheal effects of solvent fractions of H. abyssinica.

Group	Onset of diarrhea (min)	Number of wet feces	Number of total feces	% inhibition of defecation
Control	46.83 ± 3.21	9.10 ± 0.47	11.83 ± 0.60	—
CF 100 mg/kg	60.83 ± 2.12b∗	8.30 ± 0.34b∗∗∗	10.00 ± 0.72b∗∗∗	8.80
CF 200 mg/kg	72.83 ± 3.38b∗∗∗	7.60 ± 0.46b∗∗∗	8.60 ± 0.46b∗∗∗	16.50
CF 400 mg/kg	102 ± 2.47 a∗∗∗b∗	5.60 ± 0.23a∗∗∗b∗	7.20 ± 0.20a∗b∗∗∗	38.46
Loperamide 3 mg/kg	154.66 ± 6.8a∗∗∗	1.40 ± 0.2a∗∗∗	3.00 ± 0.25a∗∗∗	84.60
Control	44 ± 2.84	9.10 ± 0.47	10.00 ± 0.85	—
EAF 100 mg/kg	55.5 ± 2.64b∗∗∗	8.16 ± 0.77b∗∗∗	9.00 ± 0.85b∗∗∗	10.32
EAF 200 mg/kg	68.00 ± 3.65b∗∗∗	7.10 ± 0.83b∗∗∗	7.00 ± 0.77b∗∗∗	22.20
EAF 400 mg/kg	99.00 ± 4.15a∗∗∗b∗∗∗	3.83 ± 0.34a∗∗∗b∗∗∗	5.33 ± 0.49a∗∗b∗	57.91
Loperamide 3 mg/kg	141.00 ± 7.14a∗∗∗	1.66 ± 0.21a∗∗∗	3.10 ± 0.32a∗∗∗	76.62
Control	48.50 ± 4.52	9.10 ± 0.47	10.16 ± 0.75	—
AF 100 mg/kg	71.33 ± 8.76b∗∗∗	5.16 ± 0.47b∗∗∗	6.33 ± 0.71b∗∗∗	43.29
AF 200 mg/kg	88.65 ± 7.74a∗b∗∗∗	3.50 ± 0.42a∗∗b∗	5.50 ± 0.61a∗∗	61.53
AF 400 mg/kg	91.57 ± 10.88a∗∗b∗	2.00 ± 0.25a∗∗∗	3.66 ± 0.33a∗∗∗	78.00
Loperamide 3 mg/kg	138.50 ± 7.65a∗∗∗	1.83 ± 0.33a∗∗∗	3.60 ± 0.18a∗∗∗	80.00

Data are expressed as mean ± SEM (n = 6); analysis was performed with One-Way ANOVA followed by Tukey test; ^acompared to negative control; ^bcompared to loperamide 3 mg/kg; ^∗P < 0.05, ^∗∗P < 0.01, and ^∗∗∗P < 0.001; CF: chloroform fraction; EAF: ethyl acetate fraction; AF: aqueous fraction; negative controls received 10 ml/kg distilled water.