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. 2021 Feb 13;2021:6616422. doi: 10.1155/2021/6616422

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Copyright © 2021 Jianwei Zhang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of CPUY192018 on oxidative stress and cardiomyocyte apoptosis in septic mice. (a) Nrf2, HO-1, Nox2, Nox4, and GAPDH expression in LV tissue was detected (two-way ANOVA). (b) Serum activity of SOD and NADPH oxidase and levels of GSH and MDA were measured (two-way ANOVA). (c) AIF and Cox IV expression in mitochondria and AIF, cleaved PARP, and PCNA expression in nuclei were analyzed (two-way ANOVA). n = 5 in each group. ^∗p < 0.05 vs. the nAb DMSO+LPS group. Nrf2: nuclear factor erythroid-2 related factor 2; HO-1: heme oxygenase 1; Nox2/4: nicotinamide adenine nucleotide phosphate oxidase 2/4; nAb: anti-IL-16 neutralizing antibody; CPU: CPUY192018; LPS: lipopolysaccharide; SOD: superoxide dismutase; GSH: glutathione; NADPH: nicotinamide adenine nucleotide phosphate; MDA: malondialdehyde; AIF: apoptosis-inducing factor; Cox IV: cytochrome c oxidase IV; PARP: poly-ADP-ribose polymerase; PCNA: proliferating cell nuclear antigen.