Fig. 3.

SFRP2 and noncanonical Wnt signaling. a The Wnt/PCP pathway is characterized by the recruitment of DvL upon Wnt binding. Via two parallel signaling pathways, ROCK and JNK become activated. b In the Wnt/Ca²⁺ pathway, a cascade via several molecules eventually leads to the release of calcium from the endoplasmic reticulum. In turn, this activates calcineurin to dephosphorylate NFAT and regulates gene transcription. This figure was prepared using Servier Medical Art under a Creative Commons Attribution 3.0 Unported License