Fig. 7.

Simulations of transverse aortic constriction (TAC) interventions compared to experimental data. The multiscale model simulations of TAC interventions attenuate growth at two weeks in a manner consistent with experimental trends for a) genetic interventions GqI (Akhter et al. 1998) and NE KO (Rapacciuolo et al. 2001), b) ARB therapy (Rockman et al. 1994; Li et al. 2010; Wang et al. 2016) and c) β-blocker therapy (Patrizio et al. 2007),respectively. Data are shown as mass fold change ratio relative to control ± standard deviation of ratio