Table 2:

Data used to tune and validate the model

Tuning: Isoproterenol Infusion
Study	Isoproterenol Dose (mg/kg BW/day)	Mass Fold Change ± Standard Deviation	Time point
De Windt et al. 2001	60	1.25 ± 0.05	14 days
Tuerdi et al. 2016	5	1.37 ± 0.03	7 days
Allwood et al. 2014	30	1.36 ± 0.03	14 days
Sucharov et al. 2013	30	1.20 ± 0.04	7 days
Drews et al. 2010	30	1.16 ±0.01	1 day
	30	1.53 ± 0.08	7 days
Tshori et al. 2006	5	1.38 ± 0.14	7 days
Zhang et al. 2016	5	1.23 ± 0.01	7 days
Waters et al. 2013	47	1.27 ± 0.01	3 days
Ryu et al. 2016	25	1.31 ± 0.01	3 days
	25	1.24 ± 0.01	14 days
Jaehnig et al. 2006	60	1.29 ± 0.02	10 days
Galindo et al. 2009	40	1.49 ± 0.13	10 days
Brooks and Conrad	100	1.19 ± 0.01	14 days
Tuning: Transverse Aortic Constriction
Study		Mass Fold Change ± Standard Deviation	Time point
Liao et al. 2003		1.50 ± 0.01	7 days
Akhter et al. 1998		1.39 ± 0.13	7 days
De Windt et al. 2001		1.22 ± 0.10	14 days
Rapacciuolo et al. 2001		1.60 ± 0.23	7 days
Huss et al. 2007		1.17 ± 0.03	7 days
Choi et al. 1997		1.34 ± 0.20	7 days
Ling et al. 2009		1.65 ± 0.02	14 days
Rockman et al. 1994		1.20 ± 0.08	7 days
Li et al. 2010		1.73 ± 0.21	14 days
Wang et al. 2016		1.36 ± 0.06	14 days
Patrizio et al. 2007		1.29 ± 0.02	14 days
Validation: Transverse Aortic Constriction Plus Intervention
Study	Intervention	Mass Fold Change ± Standard Deviation	Time point
Akhter et al. 1998	GqI	1.15 ± 0.01	7 days
Rapacciuolo et al. 2001	NE KO	1.20 ± 0.03	7 days
Rockman et al. 1994	Losartan	0.96 ± 0.06	7 days
Li et al. 2010	Losartan	1.20 ± 0.01	14 days
Wang et al. 2016	Losartan	1.05 ± 0.07	14 days
Patrizio et al. 2007	Propranolol	1.15 ±0.07	14 days