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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Heart Fail Rev. 2020 Sep 3;26(2):405–415. doi: 10.1007/s10741-020-10021-5

Figure 3:

Figure 3:

Examples of engineered heart tissues (EHTs) generated for disease modeling. (a) A circular EHT consisting of hiPSC-CMs and fibroblasts was mounted in between a force transducer and a length mover (Aurora Scientific) for active mechanical measurements. (b-c) An EHT consisting of hiPSC-CMs and fibroblasts was grown between two PDMS posts (EHT Technologies). The tissue self assembles and contracts spontaneously within 5 to 7 days after seeding. (d) An EHT grown between two PDMS posts was electrically stimulated (yellow). As the tissue contracts, it displaces the PDMS posts, enabling the calculation of the force of contraction (blue) for the tissue.