Table 2. Competition for receptor binding between TGF-β family ligands.
| BMP-2 | BMP-4 | BMP-5 | BMP-6 | BMP-7 | BMP-9 | BMP-10 | Activin A | Activin B | Nodal | GDF-5 | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Activin A | ActRII5, 57 | ActRII6 | ActRII5, 9 | ActRII5, 6 | ActRII5 | ||||||
| Activin B | ActRII5 | ActRII5 | |||||||||
| Activin C | ActRII49, 55 | ActRII49 | |||||||||
| GDF-8 | ActRII5 | ActRIIB10 | |||||||||
| GDF-11 | ActRII5 | ND8 | ND8 | ND8 | ND8 | ||||||
| GDF-3 | ND177, 178 | ||||||||||
| GDF-5 | ALK3179, ND8 | ND8 | ND8 | ||||||||
| GDF-6 | ND8 | ND8 | ND8 | ||||||||
| GDF-7 | ND8 | ||||||||||
| BMP-2 | ND180, ActRIIB56 | ActRII5 | ActRII5, ND8 | ActRII5, 57 | ALK3179, ND8 | ||||||
| BMP-3 | ND8, 181 | ActRIIB51, 56, ND8 | ND8 | ND8 | ND8 | ND8 | ActRIIB51 | ||||
| BMP-3b | ND172, 181 | ND172 | ND172 | ND172 | |||||||
| BMP-7 | ActRIIA9 | ||||||||||
| BMP-8a | ND8 | ND8 | |||||||||
| BMP-9 | ActRII5 | ActRII5 | |||||||||
| BMP-10 | ActRII5, ND8 | ND8 | ActRII5 | ActRII5 | |||||||
| Inhibin | ActRII, BMPRII54 | ActRII54 | ActRII54 | ActRII48, 53, 182, 183 | ActRII54 | ||||||
| Lefty1 | ActRII52 | ||||||||||
| Lefty2 | ActRII52 |
The table provides an overview of reported competition between TGF-β family ligands, including which receptor(s) the ligands supposedly compete for in cases where this has been investigated. The ligands listed in the first row indicate agonist ligands, whereas the ligands listed in the first column indicate ligands that compete with the agonist ligands by one of our proposed modes of competition illustrated in Figure 4. In the cells, we have indicated the receptor for which the ligands compete. ActRII: indicates ActRIIA and ActRIIB, ND: Not Determined, indicates competition for an unknown receptor. The table is likely not complete since no single literature search will cover this information.