e-Table 2.

Multivariable analysis of IGF-1 and asthma hospitalization in participants with asthma (n=34,023)

	All participants	Women	Men
IGF-1 quartile (nmol/L)	Odds Ratio (95% Confidence Interval)
≥1 asthma hospitalization after IGF-1 measure	n=440	n=286	n=154
Q1 (< 17.4)	1.0	1.0	1.0
Q2 (17.4– < 21.2)	0.88 (0.68–1.15)	0.87 (0.63–1.20)	0.92 (0.57–1.48)
Q3 (21.2– < 24.8)	1.04 (0.80–1.35)	0.98 (0.71–1.35)	1.16 (0.74–1.82)
Q4 (≥ 24.8)	0.82 (0.61–1.09)	0.82 (0.58–1.18)	0.84 (0.51–1.37)
≥1 asthma hospitalization 1 year prior to or after IGF-1 measure	n=147	n=95	n=154
Q1 (< 17.4)	1.0	1.0	1.0
Q2 (17.4– < 21.2)	0.99 (0.62–1.59)	0.97 (0.56–1.71)	1.03 (0.42–2.50)
Q3 (21.2– < 24.8)	1.32 (0.84–2.07)	1.14 (0.65–2.00)	1.67 (0.75–3.76)
Q4 (≥ 24.8)	1.02 (0.62–1.68)	0.96 (0.52–1.78)	1.17 (0.49–2.80)

All models adjusted for age, sex (in all participants), ethnicity, annual household income, body mass index, smoking status, pack-years of cigarette smoking, the season of the examination, the time of the day when the examination was performed, serum level of glycated hemoglobin A1c, and C-reactive protein.

^*P <0.5

^†P <0.01

^‡P for trend <0.05