. Author manuscript; available in PMC: 2022 Mar 1.

Published in final edited form as: Ann Allergy Asthma Immunol. 2020 Dec 11;126(3):284–291.e2. doi: 10.1016/j.anai.2020.12.005

e-Table 3 –

Multivariable analysis of IGF-1 and lung function measures (as z-scores)

	All participants (n=212,462)	Women (n=113,769)	Men (n=98,693)

IGF-1 quartile	β (95% Confidence Interval)

All Participants
FEV₁ z-score	0.020 (0.016, 0.024)^*	0.021 (0.015, 0.026)^*	0.027 (0.021, 0.034)^*
FVC z-score	0.020 (0.017, 0.024)^*	0.022 (0.017, 0.027)^*	0.028 (0.022, 0.034)^*
FEV₁/FVC z-score	0.002 (−0.001, 0.006)	−0.002 (−0.006, 0.002)	0.001 (−0.004, 0.006)
Participants without asthma	n=188,123	n=100,031	n=88,092
FEV₁ z-score	0.020 (0.016, 0.024)^*	0.020 (0.014, 0.026)^*	0.025 (0.018, 0.031)^*
FVC z-score	0.020 (0.016, 0.024)^*	0.022 (0.016, 0.027)^*	0.026 (0.020, 0.032)^*
FEV₁/FVC z-score	0.003 (−0.004, 0.006)	−0.004 (−0.006, 0.002)	−0.001 (−0.006, 0.004)
Participants with asthma	n=24,339	n=13,738	n=10,601
FEV₁ z-score	0.023 (0.010, 0.036)^*	0.025 (0.008, 0.042)^*	0.049 (0.028, 0.070)^*
FVC z-score	0.027 (0.015, 0.038)^*	0.025 (0.010, 0.040)^*	0.046 (0.028, 0.064)^*
FEV₁/FVC z-score	0.001 (−0.010, 0.012)	0.003 (−0.010, 0.017)	0.017 (−0.001, 0.036)

Abbreviation: IGF-1, insulin-growth like factor 1. FEV₁, forced expiratory volume in one second; FVC, forced vital capacity.

All models adjusted for asthma status (in all participants), annual household income, body mass index, smoking status, pack-years of cigarette smoking, the season and the time of the day when the examination was performed, and serum level of glycated hemoglobin A1c, and C-reactive protein.

P <0.01