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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Cancer Metastasis Rev. 2020 Nov 6;40(1):71–88. doi: 10.1007/s10555-020-09942-2

Fig. 3.

Fig. 3.

General steps and key contributors involved in cancer extravasation. Bottom left: cell adhesive molecules (selectins, N-cadherins, integrins) mediate the adhesion of cancer cells to the endothelium; Bottom right: Cancer cells form protrusion structure (invadopodia) to transmigrate the endothelial barrier, multiple growth factors, chemokines, proteases, and extracellular vesicles secreted by either cancer cells or cancer-associated leukocytes can facilitate the transendothelial migration of cancer by disrupting the integrity of endothelial cells or increasing the motility of cancer cells.