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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Cancer Lett. 2021 Jan 10;502:25–33. doi: 10.1016/j.canlet.2020.12.044

Fig. 5. Mortalin depletion suppresses vemurafenib-resistant B-RafV600E tumor xenografts in mice.

Fig. 5.

(A) Changes in tumor sizes in athymic mice bearing xenografts of A375R stably expressing pTRIPZ-dox-shMort (dox-shM) or the control pTRIPZ. Doxycycline was administered via drinking water (details in the methods section). (B) Weights of tumors collected at the end of the treatment in (A). Horizontal dotted line indicates mean. Each symbol represents one sample. (C) Body weight changes of animals during the treatment in (A). (D) Western blotting of the homogenates of tumors in (C). C-lamin A indicates cleaved lamin A. β-actin is the control for equal protein loading. Densitometry shown in supplemental figure S7. Data in (A to C) are mean ± SEM from a single cohort of five mice per treatment group. Each mouse developed one tumor. P values are relative to pTRIPZ. * P < 0.05, *** P < 0.001 (A, two-way ANOVA with Bonferroni post-tests; B, one-way ANOVA with Dunnett post-tests).