Table 3.
HRs of mortality for KRASMUT LUAD patients and clinical characteristics from univariate and multivariate Cox regression analysis.
| Covariate | No. of patients | No. of events | Univariate analysis HR (95% CI) | p | Multivariate analysis HR (95% CI) | p |
|---|---|---|---|---|---|---|
| LAKR: | 0.021 | 0.011 | ||||
| no | 72 | 24 | 1 (reference) | 1 (reference) | ||
| yes | 26 | 11 | 2.40 (1.1 – 4.90) | 2.86 (1.28 – 6.40) | ||
| Age at diagnosis | 0.61 | 0.77 | ||||
| <65 | 46 | 17 | 1 (reference) | 1 (reference) | ||
| ≥ 65 | 52 | 18 | 0.84 (0.43 – 1.60) | 1.07 (0.50 – 2.30) | ||
| Gender | 0.14 | 0.24 | ||||
| female | 56 | 17 | 1 (reference) | 1 (reference) | ||
| male | 42 | 18 | 1.70 (0.85 – 3.30) | 1.49 (0.70 – 3.20) | ||
| Stage | ||||||
| I | 45 | 6 | 1 (reference) | 1 (reference) | ||
| II | 28 | 16 | 3.50 (1.40 –8.50) | 0.007 | 5.00 (1.86 – 13.50) | 0.001 |
| III–IV | 23 | 12 | 5.10 (2.00 – 13.20) | < 0.001 | 6.25 (2.20 – 17.80) | < 0.001 |
| Smoking history | ||||||
| <30 pack years | 31 | 10 | 1 (reference) | 1 (reference) | ||
| ≥ 30 pack years | 47 | 16 | 1.10 (0.51 – 2.50) | 0.77 | 0.75 (0.32 – 1.80) | 0.51 |
| unknown | 20 | 20 | 1.10 (0.43 – 2.70) | 0.88 | 1.12 (0.43 – 2.90) | 0.81 |