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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Acta Biomater. 2020 Dec 28;122:263–277. doi: 10.1016/j.actbio.2020.12.043

Figure 2: AFM-based compressive force-induced deformation of biological particles.

Figure 2:

Displayed in different colors are the experimental force(F)-deformation(X) spectra (solid lines) and theoretical FX-curves for bacteriophage P22 Procapsid shell (A) and Expanded bacteriophage P22 shell (B), Human Adenovirus capsid (C), and Herpes Simplex virus capsid (D). The average experimental FX-spectra (black data points) are compared with the theoretical FX-curves obtained using the FNS theory (black solid and dashed lines). The dashed lines are continuations of the solid lines, which denote the actual fit of Eqs. (7) to the experimental force-deformation data points, past the collapse transition when the particle fractures. Also shown in panel A are the Hertzian indentation regime I, beam-bending regime II and particle fracture regime III for P22 Procapsid. For Human Adenovirus showing the strong and weak mechanical response (black data points and lines), we display two average FX-spectra overlaid with the theoretical FX-curves.