Table 4.
Statistically significant immune-related gene expression differences in obese women
| Gene Annotation | Gene name | Gene symbol | BMI ≤25 kg/m2 (n=21) normalized counts | BMI ≥35 kg/m2 (n=26) normalized counts | Fold change | p-value |
|---|---|---|---|---|---|---|
| Innate immune response | Activating transcription factor 2 | ATF2 | 4081.7 | 2769.5 | 0.68 | 0.0029 |
| Autophagy related 5 | ATG5 | 273.6 | 318.5 | 1.16 | 0.0019 | |
| Complement C8 gamma chain | C8G | 465.8 | 363.5 | 0.78 | 0.0054 | |
| Collectin subfamily member 12 | COLEC12 | 178.2 | 139.2 | 0.78 | 0.0026 | |
| Interleukin 1 receptor accessory protein like 2 | IL1RAPL2 | 18.8 | 26.8 | 1.42 | 0.0056 | |
| Janus kinase 2 | JAK2 | 150.0 | 181.0 | 1.21 | 0.0054 | |
| S100 calcium binding protein A12 | S100A12 | 49.3 | 41.2 | 0.83 | 0.0040 | |
| Toll like receptor 3 | TLR5 | 162887.4 | 122280.2 | 0.75 | 0.0013 | |
| Adaptive immune response | C-C motif chemokine ligand 15 | CCL15 | 8.6 | 13.1 | 1.52 | 0.0022 |
| CD5 molecule | CD5 | 4457.4 | 3552.6 | 0.80 | 0.0007 | |
| Junctional adhesion molecule 3 | JAM3 | 662.6 | 536.2 | 0.81 | 0.0024 | |
| Programmed cell death 1 | PDCD1 | 9.6 | 15.0 | 1.56 | 0.0033 | |
| Regulation of immune response | Caspase recruitment domain family member 11 | CARD11 | 105.1 | 158.0 | 1.50 | 0.0041 |
| H2B adaptor protein 2 | SH2B2 | 58.1 | 65.5 | 1.13 | 0.0029 | |
| Cluster of differentiation (CD) molecules | Integrin subunit beta 1 | ITGB1 | 11342.2 | 10220.6 | 0.90 | 0.0041 |
| Integrin subunit beta 4 | ITGB4 | 329.5 | 518.8 | 1.57 | 0.0029 | |
| Lysosomal associated membrane protein 2 | LAMP2 | 58.2 | 72.9 | 1.25 | 0.0021 | |
| Natural cytotoxicity triggering receptor 1 | NCR1 | 34.8 | 48.1 | 1.38 | 0.0012 | |
| Toll like receptor 3 | TLR3 | 1019.8 | 906.3 | 0.89 | 0.0022 | |
| TNF receptor superfamily member 14 | TNFRSF14 | 497.8 | 593.0 | 1.19 | 0.0029 | |
| Triggering receptor expressed on myeloid cells 1 | TREM1 | 4269.1 | 3838.1 | 0.90 | 0.0002 | |
| Miscellaneous | ||||||
| Leukocyte migration | Fucosyltransferase 7 | FUT7 | 711.9 | 633.9 | 0.89 | 0.0014 |
| Humoral immune response | Paired box 5 | PAX5 | 2481.6 | 3219.3 | 1.30 | 0.0011 |
| Antigen processing and presentation | Proteasome subunit beta 7 | PSMB7 | 2242.1 | 1981.9 | 0.88 | 0.0007 |
| Transcriptional repressor | SSX family member 4 | SSX4 | 1981.9 | 1823.9 | 0.92 | 0.0022 |
| Basic cell functions | Synaptotagmin 17 | SYT17 | 30.9 | 47.9 | 1.55 | 0.0003 |
| TNF superfamily members and their receptors | TNF receptor superfamily member 18 | TNFRSF18 | 55.8 | 117.3 | 2.10 | 0.0058 |
| T-cell proliferation | Tumor protein p53 | TP53 | 23.2 | 33.0 | 1.42 | 0.0054 |