Figure 2.

cKO mice do not have altered HFD-induced weight gain and fat mass but have reduced liver weight. Stat1 mRNA in pAT and iAT (A) and Stat1 protein levels in adipocytes, CD11c⁺ MDCs, and CD11c⁻ SVCs isolated from pAT (B) of male cKO mice and littermate controls fed HFD (16 weeks). Body weight changes of male cKO mice and littermate controls fed HFD or ND (C). Total fat mass (D) and lean mass (E) determined with a PIXImus small animal densitometer and weight and relative ratio to body weight of the pAT pad (F) and liver (G) of male cKO mice and littermate controls fed ND or HFD (16 weeks). *P < 0.05. Con, control.